Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity
نویسندگان
چکیده
منابع مشابه
Curcumin Derivatives with Potential Biological Activity
Curcumin 9a, extracted from Curcuma Longa, is a strong antioxidant that offers a good protection against injuries caused by free radicals [1-3], more active than vitamin E. Curcumin possesses also a good antibacterial and antiseptic, strong antiinflammatory, intestinal disinfectant properties, being also a good stimulant for the blood circulation. [4, 5]. The paper presents the synthesis of a s...
متن کاملNovel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells
BACKGROUND AND METHODS Curcumin has extraordinary anticancer properties but has limited use due to its insolubility in water and instability, which leads to low systemic bioavailability. We have developed a novel nanoparticulate formulation of curcumin encapsulated in stearic acid-g-chitosan oligosaccharide (CSO-SA) polymeric micelles to overcome these hurdles. RESULTS The synthesized CSO-SA ...
متن کاملPoly(γ-glutamic acid)-coated lipoplexes loaded with Doxorubicin for enhancing the antitumor activity against liver tumors
The study was to develop poly-γ-glutamic acid (γ-PGA)-coated Doxorubicin (Dox) lipoplexes that enhance the antitumor activity against liver tumors. γ-PGA-coated lipoplexes were performed by electrostatistically attracting to the surface of cationic charge liposomes with anionic γ-PGA. With the increasing of γ-PGA concentration, the particle size of γ-PGA-coated Dox lipoplexes slightly increased...
متن کاملSynthesis and Antitumor Activity of Poly(organophosphazene)/ Doxorubicin Conjugates
Doxorubicin shows a wide spectrum of activity for solid tumors such as sarcomas, adenocarcinomas and melanomas, but its strong side effects including myelosuppression, extravasation reaction and cardiotoxicity have been a serious problem.1 Polymer-anticancer drug conjugates have been studied in order to improve the side effects of the anticancer drugs. In comparison with low-molecular weight an...
متن کاملOcotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent Apoptosis
The use of doxorubicin (Dox) was severely constrained by dose-dependent side effects, which might be attenuated by combining a "sensitizer" to decrease its cumulative dosage. In this study, it was investigated whether ocotillol could enhance the antiproliferation activity of Dox. MTT assays and xenograft tumor model were firstly conducted to evaluate the effect of ocotillol on the antitumor act...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2020
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics12111084